Questions, answers and discussions regarding general pathology
HomeQ: There are some distinct morphological changes associated with necrosis and apoptosis – could you give an outline of these changes in the other forms of cell death mentioned in your lecture.
Q: There are some distinct morphological changes associated with necrosis and apoptosis – could you give an outline of these changes in the other forms of cell death mentioned in your lecture.
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The autophagic PCD can be observed by the formation of double-membrane cytoplasmic vesicles – designed to engulf cellular constituents and organelles (so-called autophagosomes) that can be seen using an electron micrograph, but without proper equipment this type of cell death may look like apoptosis, because the cells become smaller and slowly disintegrate.
Pyroptosis looks much like oncosis, since these cells swell and often form blister-like eruptions of the plasma membrane causing leakage of intracellular constituents and inflammation. In contrast to oncosis, pyroptosis causes release and activation of interleukin 1beta and 18, but morphologically this cannot be detected – so pyroptosis may many times have been mistaken for oncosis.
Paraptosis is more unique, since this kind of cell death has been associated with massive formations of fluid-filled intracellular vacuoles (spaces), but without budding or blebbing of the plasma membrane. So the plasma membrane remains intact – see also the pictures in the PowerPoint presentation associated to my lecture.
The autophagic PCD can be observed by the formation of double-membrane cytoplasmic vesicles – designed to engulf cellular constituents and organelles (so-called autophagosomes) that can be seen using an electron micrograph, but without proper equipment this type of cell death may look like apoptosis, because the cells become smaller and slowly disintegrate.
Pyroptosis looks much like oncosis, since these cells swell and often form blister-like eruptions of the plasma membrane causing leakage of intracellular constituents and inflammation. In contrast to oncosis, pyroptosis causes release and activation of interleukin 1beta and 18, but morphologically this cannot be detected – so pyroptosis may many times have been mistaken for oncosis.
Paraptosis is more unique, since this kind of cell death has been associated with massive formations of fluid-filled intracellular vacuoles (spaces), but without budding or blebbing of the plasma membrane. So the plasma membrane remains intact – see also the pictures in the PowerPoint presentation associated to my lecture.